Notch Signaling Regulates Immune Responses in Atherosclerosis

Atherosclerosis is a chronic autoimmune inflammatory disease that can cause coronary artery disease, stroke, peripheral artery disease, depending on which arteries are affected. At the beginning of atherosclerosis plasma lipoproteins accumulate in the sub-endothelial space. In response, monocytes migrate from the circulation through the endothelium into the intima where they differentiate into macrophages. These early events trigger a complex immune response that eventually involves many cellular subtypes of both innate and adaptive immunity. The Notch signaling pathway is an evolutionary conserved cell signaling system that mediates cell-to-cell communication. Recent studies have revealed that Notch modulate atherosclerosis by controlling macrophages polarization into M1 or M2 subtypes. Furthermore, it is known that Notch signaling controls differentiation and activity of T-helper and cytotoxic T-cells in inflammatory diseases. In this review, we will discuss the role of Notch in modulating immunity in the context of atherosclerosis and whether targeting Notch may represent a therapeutic strategy

Quantum Computation in a radio single mode cavity: the dissipative Jaynes and Cummings Model

Our aim is to give an account, trough an analysis of a number of papers by F.Petruccione, H.J.Charmicael, J.C. Raimond and their contemporaries, of the specific answer that we gave to the problem of Open Quantum Systems dynamical evolution and how this idea evolves and develops in physical research and in the scientific debate of the following decades. Permanent solution should not been accepted from physical research, but analysis of the real work of scientists, of the difficulties they face and the ever changing solutions they offer is, we believe, part of our understanding of science and an indispensable basis for further methodological inquiries. In this paper we have chosen to analyze a dissipative Jaynes-Cummings model assuming the common electrodynamics free field for the bipartite system and an another independent bath for the cavity, so taking into account loosing of energy because of the imperfect mirrors. The Nud theorem application leads to predict new cooperative effects between the atom and the cavity mode as the creation of conditional transient entanglement, tending to become stationary as the coupling constant take a well defined value

Synthetic environmental appraisal of waste management system: an application to the Sicilian region

This paper addresses the problem of synthetically evaluating the environmental performances of urban solid waste systems. This, in fact, represents a crucial point in the management process of complex systems that local administrations are called to cope with, in order to provide decisions about policy options that involve different issues characterising the quality of life of people. Suitable methods of evaluation are clearly required for this aim. This work introduces the dashboard of sustainability and the ecological footprint approaches as aggregate indicators of the performances of solid waste management systems. The methods have been selected due to their intrinsic simplicities, provided that the required data are available, although the first one can be defined as a political tool, while the second one can be defined as a technical tool. An application of both methods to the situation of Sicily is proposed here

Improving the sustainability of transportation: environmental and functional benefits of right-turn by pass lanes at roundabouts

The functional performances of conventional roundabouts (single-lane and multi-lane) and innovative roundabouts (spiral, flower, C and turbo) can be improved through right-turn bypass lanes controlled by stop, yield or free-flow signs. The article presents evaluations of the emissions of air pollutants (carbon dioxide, nitrogen oxides, particle pollution (PM10 and PM2.5)), fuel consumption and construction, management, energetic and environmental costs in roundabouts without or with bypass lanes (controlled by stop, yield or free-flow). The suggested methodology has a general character and can be applied as a multi-parametric criterion for choosing road intersections, although, in the present paper, it has been employed only for a case study. For the aims of this research, we employed recent closed-form formulations to determine roundabout performances; moreover, we used the Copert IV® software to estimate air emissions in nine different types of vehicles. Numerous traffic simulations were carried out. The variation in the maximum hourly traffic Qmax and annual traffic QTOT provided the appropriate domains of the examined geometric layouts, both in functional and environmental terms and with regard to generalized costs, estimated for a 10-year period. It resulted that the introduction of right-turn bypasses in all arms of conventional roundabouts with a one ring lane and one lane at the entries (single-lane roundabouts) is the most cost-effective when the flows entering the roundabout are higher than Qmax = 2000 veh/h. Moreover, free-flow bypass lanes always provide greater capacity and lower delays than stop- or yield-signaled bypasses. However, with extremely high Qmax values, stop-controlled bypasses guarantee lower fuel consumption, while those with a yield sign lower total costs

Towards Nearly Zero Energy and Environmentally Sustainable Agritourisms: The Eectiveness of the Application of the European Ecolabel Brand

Tourism represents an important economic driver in Italy, being responsible for approximately 13.2% of the total GDP (a value higher than the reference European average) and for nearly 10% of the regional GDP. Among the touristic sectors, the agritourist ones show a persistent growth, experiencing in 2019 a 6.7 point percentage improvement compared to the 2017 figures. Given this situation, the transition towards a low-carbon path, aecting the building sector for some time, should also involve agritourist buildings, through the release of EU directives, member state laws, and technical rules. On the other hand, agritourism sites could be awarded the Community EU Ecolabel. Unfortunately, awarding theEUenvironmental excellence brand implies the availability of several data on building energy behavior that should then be managed by complex evaluation tools. To overcome this issue, the use of the simplified ARERA (Italian Regulatory Authority for Energy Networks and Environment) technical datasheets, issued to assess environmental improvements consequent to energy eciency interventions in the urban residential building stock, is proposed. The application of this tool totally avoids using building computer-based simulation models, thus facilitating the preparation of the EU Ecolabel request documentation by agritourism owners. Being awarded the Community EU Ecolabel also implies approaching a net zero energy condition because of a lower energy consumption and a minor recourse to fossil fuels. For this purpose, an application of an easy graphical method, previously developed for residential and commercial buildings, which visually represents improvements achievable by a given agritourism when implementing energy eciency measures, is presented

Foster Carbon-Neutrality in the Built Environment: A Blockchain-Based Approach for the Energy Interaction Among Buildings

Decarbonizing urban environments and reducing their energy consumption is one of modern society biggest commitments. In this regard, both the scientific community and international governments have been giving special consideration on improving the energy-environmental performance of mostly single buildings; recently the focus has been shifting towards a broader Positive Energy District (PED)/ Energy Community (EC) vision, from small clustered group of buildings to neighborhoods up until urban settlements. In this respect, integrating the use of renewable energy resources (RES) and actively involving building users can have a significant environmental impact on local areas. Within this framework, this work discusses the possibility of employing an innovative blockchain-based approach for the energy interaction among buildings. The blockchain technology can, in fact, be useful in managing such scenarios since it would allow to, not only consider buildings occupants behaviors, but also take into account concernings regarding the need for transparency, engagement, environmental and human health benefits, as well as the stakeholders role in the interaction/integration between PEDs/ECs and local/national electricity systems

The Landfilling of Municipal Solid Waste and the Sustainability of the Related Transportation Activities

The management of municipal solid waste is a crucial issue to address as we move toward the decarbonization of urban contexts. Not by chance, this sector plays a relevant role in the Covenant of Mayors program, whereby municipalities are called to design their own Sustainable Energy Action Plans (SECAPs). However, despite new regulations strongly pushing the recycling and reuse of materials contained in municipal waste, many cities still use large landfills. As part of the overall environmental pressure exerted by these urban systems, the transport of waste from collection points to landfills or treatment facilities must be considered in order to correctly assess the full environmental burden of waste management. To this aim, in this paper, the Ecological Footprint method is applied to the municipal solid waste management system of the city of Palermo (Sicily). The results show that the impacts produced by the means of transport used, both in the status quo and in the assumed enhanced scenario (with less municipal waste disposed to landfills in favor of recycling), are significant compared to those caused by the other segments of the waste management system. The concept of a “saved footprint” is also introduced here, in order to properly compare the two scenarios

AI Watch - Artificial Intelligence for the public sector

This the report of the 1st AI WATCH Peer Learning Workshop on the Use of and Impact of AI in Public Services organized by JRC/B6 jointly with DG CNECT/H4. The workshop discussed the current state of AI in the public sector that shows how AI is widely experimented across European countries. From the analysis of results of the JRC activities on AI for the public sector conducted as part of the AI WATCH it emerged that these technologies are mostly applied in general public services, economic affairs and health services, with most Chatbots often mentioned. Most AI based innovation, however, seems to be mostly incremental or technical, with innovation truly causing disruptions in the public service model being limited. From the discussion in working groups and plenary it also emerged that activities of the AI Watch task on AI for the public sector should prioritize on the following Policy domains: Health, Education, Public Order, Housing, Transport and Agriculture. Finally, since an important part of the debate revolved around the topic of AI and data governance, it was decided to focus the 2nd AI WATCH Peer Learning Workshop with Member States on this domain.JRC.B.6-Digital Econom